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Fig. 7 | BMC Biology

Fig. 7

From: The role of juvenile hormone and insulin/TOR signaling in the growth of Manduca sexta

Fig. 7

A model showing the effects of JH and insulin/TOR signaling on the timing of metamorphosis. (Left) The attainment of nutrition-sensitive critical weight is influenced by insulin signaling in the prothoracic glands [12], whereas the attainment of the size-sensitive critical weight determines the time when JH is cleared from the hemolymph [5]. Depending on the time when the size-sensitive critical weight is attained, the relative contribution of insulin signaling on the final body size changes. The model shows how JH and insulin/TOR signaling influence the growth of wild-type, black mutant, and allatectomized Manduca, and Drosophila [12, 14, 19]. (Right) The seesaw diagrams represent the mechanisms underlying trade-offs between maximizing body size and faster development. The relative contributions of JH signaling and insulin/TOR signaling pathways differ between Manduca and Drosophila: maximal body size is favored in Manduca, whereas developmental speed is favored in Drosophila

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