TY - JOUR AU - Evans, Jennifer A. AU - Suen, Ting-Chung AU - Callif, Ben L. AU - Mitchell, Andrew S. AU - Castanon-Cervantes, Oscar AU - Baker, Kimberly M. AU - Kloehn, Ian AU - Baba, Kenkichi AU - Teubner, Brett J. W. AU - Ehlen, J. Christopher AU - Paul, Ketema N. AU - Bartness, Timothy J. AU - Tosini, Gianluca AU - Leise, Tanya AU - Davidson, Alec J. PY - 2015 DA - 2015/06/23 TI - Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body JO - BMC Biology SP - 43 VL - 13 IS - 1 AB - Daily rhythms in mammals are programmed by a master clock in the suprachiasmatic nucleus (SCN). The SCN contains two main compartments (shell and core), but the role of each region in system-level coordination remains ill defined. Herein, we use a functional assay to investigate how downstream tissues interpret region-specific outputs by using in vivo exposure to long day photoperiods to temporally dissociate the SCN. We then analyze resulting changes in the rhythms of clocks located throughout the brain and body to examine whether they maintain phase synchrony with the SCN shell or core. SN - 1741-7007 UR - https://doi.org/10.1186/s12915-015-0157-x DO - 10.1186/s12915-015-0157-x ID - Evans2015 ER -