From: Accurate chromosome segregation by probabilistic self-organisation
Parameter for | Range of values | Biological meaning | |
---|---|---|---|
n | Maximal number of kMTs | 2≤n | Maximal number of kMTs that can be accommodated on a single |
per kinetochore | kinetochore. n is proportional to the size of a kinetochore. | ||
p | Association probability | 0≤p≤1/4 | 2×p is the association probability of a single microtubule to a free |
kinetochore in each discrete time step. Upper limit of p is 1/4 | |||
because total probability ≤1. | |||
q | Dissociation probability | 0≤q≤1/2n | Dissociation probability of a single kMT in each discrete time step. |
α | Scaling factor of p | 0≤α≤1 | Scaling applies to transitions from amphitelic (class 5) to merotelic |
(class 4) states; reflecting the physical constraint imposed in | |||
amphitelic states (meiosis I) or the back-to-back position of sister | |||
kinetochores (mitosis). α=0 in mitosis for simplicity. | |||
β | Scaling factor of q | 0≤β≤1 | Scaling applies to transitions in/from amphitelic states (class 5); |
reflecting the kMT stabilisation by tension. | |||
γ | Scaling factor of p | 0≤γ≤1 | Scaling applies to transitions from monotelic (class 2) to syntelic |
(class 3) or merotelic (class 4) states in mitosis; reflecting the | |||
biased orientation of sister kinetochores in monotelic states. |