Skip to main content


Fig. 1 | BMC Biology

Fig. 1

From: GDF-5 can act as a context-dependent BMP-2 antagonist

Fig. 1

Architecture of the binary GDF-5 R57A:BMPR-IAEC complex. Ribbon plot of the binary complex of GDF-5 R57A (monomer subunits colored in blue and cyan) bound to the extracellular domain of BMPR-IA (green). a View from the side, the side facing the putative cell surface is indicated. b As in (a) but viewed from the top showing the two-fold symmetry of the homodimeric GDF-5 as well as of the ligand-receptor complex. Disulfide bonds forming the two cystin-knot motifs in the GDF-5 monomer subunits and the intermolecular disulfide bond are shown as yellow sticks. The location of the knuckle epitope important for BMP type II receptor binding is indicated

Back to article page