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Fig. 7 | BMC Biology

Fig. 7

From: GDF-5 can act as a context-dependent BMP-2 antagonist

Fig. 7

Ligand implantation assay in rat. Insoluble collagenous bone matrix cylinders doped with BMP-2, GDF-5, or GDF-5 R57A were implanted into a hind-limb muscle (a) or the calvaria (b) of male adult Sprague Dawley rats with a body weight of 400 ± 50 g. The cylinders were explanted 28 days post implantation and radiographs of the specimen were taken. Bone regeneration was assessed by quantifying the area of newly formed bone of the total explant (c) or in the defect site (d)

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