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Fig. 7 | BMC Biology

Fig. 7

From: Structure and function of mitochondrial membrane protein complexes

Fig. 7

Cryo-EM structure of the 1.7 MDa bovine heart respiratory chain supercomplex. a The supercomplex consists of one copy of NADH dehydrogenase (complex I, blue), a cytochrome b-c 1 dimer (complex III, pink), and a single copy of cytochrome c oxidase (complex IV, green). b The ubiquinol (UQ) binding sites of complexes I and III and the short distance between the cytochrome c binding sites in complexes III and IV, which would favor efficient electron transfer. Cofactors active in electron transport are marked in yellow (FMN), orange (iron–sulfur clusters), dark blue (quinols), red (hemes), and green (copper atoms). Arrows indicate the electron path through the supercomplex. (Adapted from [51])

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