Fig. 4
From: Quantitative framework for ordered degradation of APC/C substrates
Varying k c and k d influences T95 differently depending on amount of free APC/C. Each dot represents one pair of (k c ,k d ) values, and the color corresponds to the quantity of interest shown on the example profiles on the left. In all panels, k a  = 0.01/(nM sec). a Middle panel: dot color indicates the duration of T95 (in seconds) at different k c -k d combinations. Right panel: a close-up of the parameter region that meets both T95 and Td requirements (as in Fig. 3c center panel), with an adjusted color scale. b Middle panel: at each k c -k d combination, dot color indicates the relative decrease of T95 when k c was increased by a factor of 1.8. Below are substrate degradation profiles showing the effect of increasing k c by a factor of 1.8 at the parameter combinations indicated by the dotted lines. Right panel: dot color indicates the relative decrease of T95 when k d was decreased by a factor of 1.8. Below are substrate degradation profiles showing the effect of decreasing k d by a factor of 1.8 at the parameter combinations indicated by the dotted lines. c Dot color indicates the maximum fraction of APC/CCdc20 that is bound to S during the degradation process. See Additional file 1: Figure S7 for plots at different values of the association rate constant k a . APC/C anaphase-promoting complex/cyclosome