Fig. 2
Dietary nitrate enhances fatty acid oxidation and mitochondrial biogenesis in skeletal muscle. (a) Fatty acid profile of soleus tissue divided into ≥ C16 (longer-chain) and < C16 (shorter-chain); (b) Respiration rates with palmitoyl-carnitine and malate substrates in permeabilized soleus muscle fibres; (c) Citrate synthase activity in soleus tissue; (d) 14C-Palmitate oxidation rates in mitochondrial isolates from soleus muscle; (e) 3-hydroxyacyl-CoA dehydrogenase activity in soleus tissue; (f) CPT1 activity in mitochondrial isolates from soleus muscle; (g) Malonyl-CoA levels in soleus tissue extracts; (h) Malonyl-CoA decarboxylase protein levels in soleus tissue. Data are represented as mean ± SEM, n = 4–6 per experimental group. * P ≤0.05; ** P ≤0.01; *** P ≤0.001