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Fig. 3 | BMC Biology

Fig. 3

From: Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism

Fig. 3

Dietary nitrate enhances fatty acid oxidation in skeletal muscle via enhanced PPARα and PPARβ/δ activity. (a) Levels of cAMP and cGMP in soleus extracts from rats supplemented with control (0 mM), low (0.35 mM), medium (0.7 mM) and high (1.4 mM) doses of dietary nitrate; (b) PPARα and PPARβ/δ expression in soleus tissue; (c) PPARα and PPARβ/δ DNA-binding in nuclear extracts of soleus; (d) Respiration rates and respiratory control ratio with palmitoyl-carnitine and malate substrates in permeabilized soleus muscle fibres from wild-type and PPARα−/− mice; (e) PPARα and PPARβ/δ DNA-binding in nuclear extracts of soleus from wild-type mice and PPARα−/− mice. Data are represented as mean ± SEM, n = 3–8 per experimental group. * P ≤0.05; ** P ≤0.01; *** P ≤0.001

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