Fig. 4

Domain architectures and structural analyses of NLR-kinase fusions. a Distribution of identified integrated kinase domains. b Complex fusions of domains on top of NLR-kinases. c Three-dimensional structural model of the kinase domain of an Arabidopsis NLR-kinase At4G12020 (aa 8–258) modelled after the best structural match, human serine/threonine protein kinase PAK 6 (PDB: 2C30). Conservation profile across all plant kinases found in NLR-IDs is overlapped on the structure, with most conserved residues depicted in red and most divergent in blue. d Zoom-in on the active site and its critical lysine and aspartate residues and a corresponding alignment logo show that the active site of kinases is completely conserved across all fusions