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Fig. 8 | BMC Biology

Fig. 8

From: Alternative cleavage and polyadenylation in spermatogenesis connects chromatin regulation with post-transcriptional control

Fig. 8

Widespread activation of upstream antisense RNA expression in spermatogenesis. a Schematic of upstream antisense RNA (uaRNA). An uaRNA is defined as an antisense transcript with pA located within 2 kb from the transcription start site (TSS) of a gene. b uaRNA expression is significantly upregulated in spermatogenesis. 3’READS data were used for the plot. Reads per million (RPM) value was assigned to each pA location. c Relationship between uaRNA expression and sense RNA expression at different time points. Correlation is indicated by the Pearson correlation coefficient (r) and P value for linear regression. d ChIP-seq analysis of H3K4me3 levels on genes with uaRNA regulation. Enrichment scores of H3K4me3 +/− 4 kb around the TSS are plotted for genes with upregulated uaRNAs or other genes. P values were based on the Wilcoxon rank-sum test comparing RPM values of the two gene groups in the +/− 1 kb region from the TSS

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