Fig. 12

Diurnal variations of the glucose exchange flux and glycogen in the fed state. (a) Measured diurnal profiles of plasma glucose for fed hepatocytes taken from [56] and used as model input. (b, c) Diurnal profiles of insulin and glucagon calculated from the plasma glucose profile in (a) by means of the GHT function. (d) Simulated diurnal glucose exchange flux. (e) Simulated diurnal glycogen content in fed hepatocytes. The simulation was repeated 50 times with uniformly sampled protein abundances from the observed range for each enzyme (Table 1)