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Fig. 16 | BMC Biology

Fig. 16

From: The relative importance of kinetic mechanisms and variable enzyme abundances for the regulation of hepatic glucose metabolism – insights from mathematical modeling

Fig. 16

Influence of different levels of metabolic control on diurnal glucose exchange rates. Black curves: Full control – enzyme abundances are adapted to the fed (a) and fasted (b) state (Table 1) with full allosteric and hormonal control. Blue curves: No change of enzyme abundance – enzyme abundances of fed and fasted livers are the same as in the normal liver; full allosteric and hormonal control. Green curves: Lacking hormonal control – enzyme abundances are adapted to the fed (a) and fasted (b) state with full allosteric control. The value of the function γ controlling the ration between the phosphorylated and non-phosphorylated form of all enzymes is put to the constant value of 0.32, which holds at the reference case (= set point of the normal hepatocyte). Red curves: No allosteric regulation – enzyme abundances were adapted to the fed (a) and fasted (b) state, with full hormonal control. The saturation terms for allosteric effectors in the enzymatic rate equations were fixed to the values achieved in the reference state

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