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Table 1 Relative maximal enzyme activities for the normal, fasted, and diabetic rat liver. The numbers represent relative maximal enzyme activities with respect to those of the fed state (= reference state). They are based on the experimentally observed protein abundance ratios shown in Fig. 1. For the absolute values of maximal enzyme activities in the fed (reference) state see section model parameters in Additional file 1. Where there is no range given, only the given fixed ratio was used

From: The relative importance of kinetic mechanisms and variable enzyme abundances for the regulation of hepatic glucose metabolism – insights from mathematical modeling

Enzyme Normal liver Fasted liver Diabetic liver
  mean mean range mean range
FBP1 1.00 1.00 4.00
FBP2 0.66 0.43 0.4–0.475 0.26 0.20–0.40
GK 0.48 0.23 0.12–0.46 0.24 0.19–0.33
GlcT 1.00 1.00 1.35 1.00–2.00
GP 0.89 0.80 0.65–1.0 0.45 0.40–0.63
G6P 1.41 2.00 3.54 1.48–7.07
GS 1.00 1.00 1.70 1.24–2.25
PC 1.25 1.56 3.75 2.50–5.00
PEPCK 1.41 2.00 4.24 2.83–5.66
PFK1 0.76 0.57 0.3–0.85 0.30 0.23–0.41
PFK2 0.66 0.43 0.4–0.475 0.26 0.20–0.40
PK 0.58 0.33 0.25–0.5 0.29 0.17–0.52
  1. FBP1 Fructose-1,6-bisphosphatase, FBP2 Fructose-2,6-bisphosphatase, GK Glucokinase, GlcT Glucose transporter, G6P Glucose-6-phosphate phosphatase, GP Glycogen phosphorylase, GS Glycogen synthase, PC Pyruvate carboxylase, PEPCK Phosphoenolpyruvate carboxykinase, PFK1/2 Phosphofructokinase-1/2, PK Pyruvate kinase