Fig. 12
AHR down-regulation decreases the efficiency of tumor formation in vivo. Titered numbers (10,000, 5,000, or 2,500) of sorted ALDHhigh or ALDHlow dox-inducible shAhr-transduced SUM149 cells were grafted into the mammary fat pads of NOD/SCID mice (six mice/group). Mice were given water + 5 % sucrose or water with doxycycline + 5 % sucrose to induce the shAhr. Data are presented as mean tumor volume ± standard error. Asterisks indicate a significant difference in tumor volume, P <0.05. Statistical analyses were not performed when none of the mice in a given control group developed tumors at that time point