Fig. 6

AHR down-regulation decreases migration of SUM149 cells. (a) Presented are representative images of SUM149 cell migration at 24 and 48 hours after cells were sorted into ALDH^high and ALDH^low populations, cultured to confluence, scratched, and treated with vehicle or 10 μM CH223191. Data are representative of three independent experiments. Black lines indicate the borders of the original scratch. (b) SUM149 cells were treated as in (a) and percent exposed area was quantified. Data from three experiments were normalized to results obtained with naïve cells and presented as mean percent exposed area ± standard error. Asterisks indicate a significant increase in exposed area, *P <0.05, **P <0.0005. A cross indicates a significant decrease in exposed area, ⁺ P <0.05