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Table 1 Consensus aryl hydrocarbon receptor response elements (AHREs) in human stem cell- and migration/invasion-associated gene promoters

From: The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells

 

Gene

# of Consensus AHREs and location relative to TSS

Standard

Cyp1b1

8 (−206, −267, −840, −859, −944, −1028, −1678, −2392)

Stem cell markers

Aldh1a1

0

Sox2

7 (−617, −749, −1284, −1430, −1678, −2577, +59)

Nanog

9 (−83, −140, −169, −430, −683, −1076, −2019, −2103, +146)

Dppa3

NA

Pou5f1

3 (−1403, −2203, −2289)

Bmi1

5 (−64, 328, −369, −2275, −2428)

Notch1

13 (−75, −284, −367, −655, −743, −982,-1270, −1838, −1844, −2114, −2140, +52, +196)

Notch2

NA

Msi1

7 (−270, −559, −904, −1821, −2114, −2686, +190)

Invasion and migration markers

Snai1

5 (−82, −148, −1836, −1944, +216)

Twist1

NA

Vim

6 (−360, 384, −927, −1003, +224, +294)

Twist2

2 (−314, −2114)

Tgfb1

5 (−836, −1936, −2037, −2190, −2734)

Snai2

5 (−576, −2016, −2821, −2823, +50)

Fn1

1 (−2023)

  1. Consensus AHREs were searched up to 3,000 bp upstream and 300 bp upstream of the transcription start site using Transcriptional Regulatory Element Database (http://rulai.cshl.edu)