TY - JOUR AU - Bagchi, Rushita A. AU - Roche, Patricia AU - Aroutiounova, Nina AU - Espira, Leon AU - Abrenica, Bernard AU - Schweitzer, Ronen AU - Czubryt, Michael P. PY - 2016 DA - 2016/03/17 TI - The transcription factor scleraxis is a critical regulator of cardiac fibroblast phenotype JO - BMC Biology SP - 21 VL - 14 IS - 1 AB - Resident fibroblasts synthesize the cardiac extracellular matrix, and can undergo phenotype conversion to myofibroblasts to augment matrix production, impairing function and contributing to organ failure. A significant gap in our understanding of the transcriptional regulation of these processes exists. Given the key role of this phenotype conversion in fibrotic disease, the identification of such novel transcriptional regulators may yield new targets for therapies for fibrosis. SN - 1741-7007 UR - https://doi.org/10.1186/s12915-016-0243-8 DO - 10.1186/s12915-016-0243-8 ID - Bagchi2016 ER -