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Fig. 7 | BMC Biology

Fig. 7

From: Hmga2 is necessary for Otx2-dependent exit of embryonic stem cells from the pluripotent ground state

Fig. 7

Enhancer activation in wildtype (wt) and Hmga2 knockout (KO) cells. a The activation of the indicated enhancers was analyzed by measuring the levels of H3K27ac by ChIP-qPCR in undifferentiated and differentiated wt and Hmga2 KO induced pluripotent stem cells (iPSCs). qPCR data represent means of two independent experiments (n = 2) ± SD for each of the indicated wt or Hmga2 KO iPSC clones. b The levels of H3K27ac on Oct6 enhancer were measured by ChIP-qPCR in undifferentiated and differentiated wt and Hmga2 KO iPSCs. The right panel reports the ChIP of Hmga2 that demonstrates the absence of binding to the Oct6 enhancer in EpiLCs. qPCR data represent means of two independent experiments (n = 2) ± SD for two wt iPSC clones

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