TY - JOUR AU - Navarro, Gemma AU - Cordomí, Arnau AU - Zelman-Femiak, Monika AU - Brugarolas, Marc AU - Moreno, Estefania AU - Aguinaga, David AU - Perez-Benito, Laura AU - Cortés, Antoni AU - Casadó, Vicent AU - Mallol, Josefa AU - Canela, Enric I. AU - Lluís, Carme AU - Pardo, Leonardo AU - García-Sáez, Ana J. AU - McCormick, Peter J. AU - Franco, Rafael PY - 2016 DA - 2016/04/05 TI - Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs JO - BMC Biology SP - 26 VL - 14 IS - 1 AB - G-protein-coupled receptors (GPCRs), in the form of monomers or homodimers that bind heterotrimeric G proteins, are fundamental in the transfer of extracellular stimuli to intracellular signaling pathways. Different GPCRs may also interact to form heteromers that are novel signaling units. Despite the exponential growth in the number of solved GPCR crystal structures, the structural properties of heteromers remain unknown. SN - 1741-7007 UR - https://doi.org/10.1186/s12915-016-0247-4 DO - 10.1186/s12915-016-0247-4 ID - Navarro2016 ER -