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Fig. 10 | BMC Biology

Fig. 10

From: Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta

Fig. 10

APP CTF and sAPPβ production are reduced in the absence of Syt1. Western blot analysis of the APP processing in PC12 (aendogenous APP) and CHO (bstably overexpressed human APP) cells. The levels of sAPPβ, sAPPα, and APP CTFs (total) were normalized to FL APP. Data are presented as mean ± SEM, (A) n = 6 for APP CTF and n = 8 for sAPPβ, (B) n = 7 for APP CTF, n = 6 for sAPPα, n = 5 for sAPPβ. Statistical significance was determined using the unpaired student t-test, * p < 0.05, ** p < 0.01, *** p < 0.001. APP amyloid precursor protein, sAPPβ secreted APPβ, Syt1 synaptotagmin 1, CHO Chinese hamster ovary cells, CTF C-terminal fragment, FL full length

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