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Fig. 8 | BMC Biology

Fig. 8

From: Mechanosensory organ regeneration in zebrafish depends on a population of multipotent progenitor cells kept latent by Schwann cells

Fig. 8

Schematic representation of neuromast regeneration from interneuromastic cells (INCs). a A schematic representation of the four stages identified here during regeneration of a whole neuromast. I, after neuromast ablation, a remaining INC that has multipotent progenitor properties (green with blue nucleus, ET20:GFP+) becomes activated; II, the INC divides, and daughter cells accumulate where the original neuromast was and acquire expression of Sox2 (green with red nuclei; ET20:GFP+, Sox2+); III, mantle cells (brown) differentiate at the periphery of the cell cluster while central cells lose GFP expression (ET20:GFP, Sox2+), becoming neuromast progenitor cells; IV, neuromast regeneration is achieved when hair cells (blue) differentiate. b Differentiation pathway of INCs during neuromast regeneration. It is unclear from our study whether INC progeny can differentiate directly into the mantle cells (MC) or whether MCs differentiate from a proliferative INC (pINC*) (an ET20+Sox2+Brn3c cell). The pINCs accumulate and can differentiate into a neuromast progenitor cell (PC), losing the ET20 marker. Finally, the acquisition of Brn3c expression (hair cells, HC)

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