Fig. 7From: The human Na+/H+ exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2Scaffolding of ERK2 by the intrinsically disordered NHE1cdt via a “shuffle complex”. Suggested topology of the hNHE1cdt-iaERK2 complex indicating the tripartite binding mode between hNHE1cdt and human iaERK2. a–b As NHE1 functions as a dimer in the cell, one or both NHE1s in a dimer can shuffle an ERK1/2. c Alternatively, one NHE1 binds ERK1/2, whereas the other NHE1 in the dimer can scaffold other members of the signalling complex. Alternating conformations are indicated encompassing the individual sites and combinationsBack to article page