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Fig. 1 | BMC Biology

Fig. 1

From: Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection

Fig. 1

Oligomerization model of Irga6 proposed by Martens in 2004 [15]. Irga6 (labelled according to the old nomenclature as IIGP1) shuttles between endoplasmic reticulum membranes and cytosol. Nucleotide-dependent oligomerization of Irga6 is prevented at the membrane by a yet unknown factor (X). X is missing from the Toxoplasma gondii parasitophorous vacuole allowing Irga6 oligomerization at the vacuole

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