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Table 3 Enrichment of functional classes among 278 Nipi genes

From: A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes

Category/Phenotype upon RNAia Number over-lapping genes Total number genes in class Percentage of MAPK signaling genes in class Probabilityb
1. Conserved in D. melanogaster c as described in [124] 169 3710 84.8 3.77 × 10−54
2. Stimulate microbial aversion behaviorc [26] 65 374 33.3 1.39 × 10−50
3. Suppress over-expression of gpdh-1p::gfp seen in osm-8 mutantc,d [72] 52 252 24.2 7.87 × 10−44
4. Decrease acdh-1p::gfp expression [73] 35 146 6.1 3.33 × 10−31
5. Induce hsp-6p::gfp (mitochondrial UPR) [66] 30 95 0.0 1.60 × 10−30
6. Protein expression [125] 43 446 9.1 1.18 × 10−21
7. Required for cytoprotective response – four different reporter genesc [49] 21 71 24.2 3.08 × 10−20
8. Required for transgene silencing [57] 50 823 24.2 1.25 × 10−16
10. Alter RAB-11 sub-cellular localization and transport of the apical membrane protein PEPT-1 [79] 34 426 15.2 3.40 × 10−14
11. Synthetic phenotype with lin-35 [126] 27 252 6.1 3.95 × 10−14
12. Required for mitochondrial surveillance and response [74] 14 45 9.1 2.08 × 10−13
13. Regulators of gpdh-1 expressiond [75] 18 123 6.1 2.45 × 10−11
15. Aberrant GFP::PGL-1 phenotypes [76] 20 170 12.1 6.87 × 10−11
16. Suppressors of polyglutamine aggregation [77] 19 173 9.1 9.65 × 10−10
17. Mitochondrial [125] 17 160 0.0 2.35 × 10−8
18. Upregulated after 12 h of dauer recovery [127] 44 1175 12.1 3.31 × 10−7
20. Altered expression in zpf-1 mutant [128] 21 333 3.0 2.24 × 10−6
21. Down regulated in an ogt-1 mutant [129] 30 670 9.1 4.02 × 10−6
22. Altered expression in rde-4 mutant [128] 17 232 6.1 7.17 × 10−6
23. Induce hsp-70p::gfp [130] 9 52 9.1 1.03 × 10−5
24. Genes connected to miRNA function [131, 132] 8 42 9.1 2.79 × 10−5
25. Increase longevity [133] 9 66 3.0 8.78 × 10−5
26. Induced after 24 h of D. coniospora infection (cDNA microarrays) [2] 21 419 12.1 1.12 × 10−4
27. Confer hypoxia-resistance [134] 14 198 9.1 1.98 × 10−4
29. Induce irg-1p::gfp [59] 10 102 0.0 4.37 × 10−4
31. Energy generation [125] 10 104 3.0 5.23 × 10−4
  1. aThe numbers refer to the order of the classes in the complete analysis; some redundant or similar classes have been removed (see Additional file 7: Table S6 for complete data)
  2. bBonferroni-corrected Fischer exact score
  3. cClass significantly enriched in the group of 33 “non-his non-msp MAPK pathway genes”
  4. dClass related to osmotic stress response