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Table 5 Foundling Nipi genes

From: A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes

Gene/sequence name Brief description
dcar-1 GPCR receptor; activated by HPLA [20]
elo-2 Palmitic acid elongase; ELO-2 is required with ELO-1 for 20-carbon PUFA production
frpr-11 GPCR of the FMRFamide Peptide Receptor family; unlike dcar-1, acts downstream of gpa-12 and blocks osmotic induction of nlp-29 [20]
ins-6 Predicted type-beta insulin-like peptide
mltn-12 MLt-TeN (mlt-10) related; MLT-10 is a nematode-specific protein required for ecdysis
nas-37 Astacin-class metalloprotease required for ecdysis; N-terminal signal sequence followed by an Astacin protease domain and three protein-binding domains (EGF-like, CUB, and thrombospondin)
srsx-25 GPCR of the serpentine receptor class SX
srv-21 GPCR of the serpentine receptor class V; unlike dcar-1, acts downstream of gpa-12 and blocks osmotic induction of nlp-29 [20]
sta-2 STAT family of transcription factor [7]
F56A8.5 Protein containing an F-box
K08C9.5 Protein containing an F-box
C33D9.3 Nematode-specific
F27C8.2a Nematode-specific
F27C8.3a Nematode-specific
F34H10.1 Ubiquitin/40S ribosomal protein S27a fusion protein
K08C9.7 Ubiquitin/40S ribosomal protein S27a fusion protein
R186.8 39S ribosomal protein L33, mitochondrial
T08D2.2b Similar to C-terminal half of UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase
T08D2.6b YIPF4-like; YIPF4, poorly characterized membrane spanning protein; in yeast, interacts with Rab GTPases
Y60A3A.19 YIPF4-like.;YIPF4, poorly characterized membrane spanning protein; in yeast, interacts with Rab GTPases
C42C1.3 Nematode-specific
F35F10.14 Nematode-specific
F41H8.1c Nematode-specific domain: GPCR of the serpentine receptor class BC
K09C6.6c Nematode-specific domain: GPCR of the serpentine receptor class BC
K09C6.10c Nematode-specific
F42C5.9 Actin
F45E4.5 Nematode-specific
F49H12.5 Thioredoxin domain-containing protein 12-like
F52C6.13 Nematode-specific
tsen-54 N-terminal half similar to that of tRNA-splicing endonuclease subunit Sen54
Y39G10AR.7 Nematode-specific
Y51H7BR.7 Contains Spec3 domain, like Drosophila Stumbled
Y67D8C.22 Clarin-like
  1. a,bTargeted by a single mv clone
  2. cPotential targets of the same sjj clone
  3. References are given for genes previous connected to the regulation of nlp-29 expression; see Additional file 7: Table S6