Fig. 5
From: Evolutionary origin and functional divergence of totipotent cell homeobox genes in eutherian mammals
Nuclear localisation and transcriptional activity. a Confocal images of fibroblasts transfected with V5-tagged constructs or empty vector control, showing nuclei (blue DAPI), ectopic protein (red) and, in the merged images, actin cytoskeleton (green phalloidin). b Numbers of genes up- and down-regulated by ectopic expression and overlaps between responsive gene sets. The clearest overlap is between TPRX1 and LEUTX down-regulated genes. For stringency criteria, see Methods