TY - JOUR AU - Chen, Lei AU - Guo, Weiwei AU - Ren, Lili AU - Yang, Mingyao AU - Zhao, Yaofeng AU - Guo, Zongyi AU - Yi, Haijin AU - Li, Mingzhou AU - Hu, Yiqing AU - Long, Xi AU - Sun, Boyuan AU - Li, Jinxiu AU - Zhai, Suoqiang AU - Zhang, Tinghuan AU - Tian, Shilin AU - Meng, Qingyong AU - Yu, Ning AU - Zhu, Dan AU - Tang, Guoqing AU - Tang, Qianzi AU - Ren, Liming AU - Liu, Ke AU - Zhang, Shihua AU - Che, Tiandong AU - Yu, Zhengquan AU - Wu, Nan AU - Jing, Lan AU - Zhang, Ran AU - Cong, Tao AU - Chen, Siqing AU - Zhao, Yiqiang AU - Zhang, Yue AU - Bai, Xiaoqing AU - Guo, Ying AU - Zhao, Lidong AU - Zhang, Fengming AU - Zhao, Hui AU - Zhang, Liang AU - Hou, Zhaohui AU - Zhao, Jiugang AU - Li, Jianan AU - Zhang, Lijuan AU - Sun, Wei AU - Zou, Xiangang AU - Wang, Tao AU - Ge, Liangpeng AU - Liu, Zuohua AU - Hu, Xiaoxiang AU - Wang, Jingyong AU - Yang, Shiming AU - Li, Ning PY - 2016 DA - 2016/06/27 TI - A de novo silencer causes elimination of MITF-M expression and profound hearing loss in pigs JO - BMC Biology SP - 52 VL - 14 IS - 1 AB - Genesis of novel gene regulatory modules is largely responsible for morphological and functional evolution. De novo generation of novel cis-regulatory elements (CREs) is much rarer than genomic events that alter existing CREs such as transposition, promoter switching or co-option. Only one case of de novo generation has been reported to date, in fish and without involvement of phenotype alteration. Yet, this event likely occurs in other animals and helps drive genetic/phenotypic variation. SN - 1741-7007 UR - https://doi.org/10.1186/s12915-016-0273-2 DO - 10.1186/s12915-016-0273-2 ID - Chen2016 ER -