Fig. 1
From: A de novo silencer causes elimination of MITF-M expression and profound hearing loss in pigs
Cochlear morphology and auditory electrophysiology defects of albino pigs. a Gross image of a normal pig and an albino pig. b Results of auditory brainstem response tests showing profound hearing loss of albino pigs. The raw data is provided in Additional file 5: sheet 1 Data of ABR tests (pigs). c Scanning electron microscopy images showing missing or fused (star) stereocilias of inner (arrow) and outer (arrowhead) hair cells in albino pigs. d Images showing that the stria vascularis (SV) of albino pig are remarkably thinner than that of normal pig. e Image showing lack of intermediate cells in the SV of albino pigs. Marginal cell layer, arrowheads; intermediate cell, stars; basal cell, arrows; spiral ligament, Spl. f and g The average values of endolymphatic potential and scala media potassium concentration in albino pigs were significantly lower than in normal pigs (raw data in Additional file 5: sheet 2 Data of EP and sheet 3 Data of K+ concentration). Error bars indicate the standard deviations. Scale bars in c = 100 μm, in d = 50 μm, and in e = 5 μm