Fig. 6
From: A de novo silencer causes elimination of MITF-M expression and profound hearing loss in pigs
Schematics showing the genetic effect of the causative mutation. In Mitf  R/R stria vascularis (SVs) (before duplication). SOX proteins cannot recognize and bind to the M-promoter and MITF-M was normally transcribed. In Mitf  r/r SVs, a new consensus site for SOX protein binding, which resulted from the 14-bp duplication, created a de novo silencer in the M-promoter. SOX proteins ectopically binding to that silencer may repress the transcription of Mitf-m (after duplication)