Fig. 8
Epistasis experiments. Injection of antisense morpholinos specific for xWnt5a (Wnt5aMo), xWnt11 (Wnt11Mo), pbk (pbkMo), and rab11fip5 (rabMo) impaired convergent extension movements as seen as mild phenotype by a shortened and broad chordin expression or a strong phenotype by a blurred chordin expression or a staining at the borders of the non-closing blastoporus. a Shows representative dorsal marginal zone explants. b Quantification of the epistasis experiments revealed that knock-down of pbk can compensate for the loss of xWnt5a, but (c) knock-down of rab11fip5 cannot compensate for the loss of xWnt11. Shown is the absolute frequency of the indicated phenotypes. The superimposed error bars illustrate the variation between N biological replicates. ** P < 0.01, *** P < 0.001 according to the χ2 test, n: number of analyzed embryos