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Fig. 5 | BMC Biology

Fig. 5

From: Type IV collagen drives alveolar epithelial–endothelial association and the morphogenetic movements of septation

Fig. 5

Abnormal microvasculature and endothelial–epithelial association in Col4a1 +/Δex41 mice. ad Co-staining of Ki67 and CD31 shows active endothelial proliferation (arrows) at E18.5. e Endothelial cells stained with CD31 exhibit the characteristic double capillary layer of the saccular stage (i). f In contrast, Col4a1 +/Δex41 vascular plexus is disorganized within the interstitium and the alveolar epithelium marked with PDPL (j). Co-localization of PDPL and CD31 shows abnormal development of the blood–gas barrier in Col4a1 +/Δex41 at P6 (g, h, k, l) and P30 (m, n, p, q). o, r Tie2-Cre; Col4a1 +/Flex41 mice also show a disorganized endothelium–epithelium association. Scale bars = 20 μm in ad, and 100 μm in eh and mo

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