Fig. 4

Difference between accessibility distributions of positions with or without SNP within a given range of accessibilities (0–0.1, 0.1–0.2, 0.2–0.3, 0.3–0.4, 0.4–0.5, 0.5–0.6, 0.6–0.7, 0.7–0.8, 0.8–0.9, 0.9–1). Probabilities within ranges were calculated using the integrate.xy function on a density distribution (see Methods). Vertical lines represent the confidence intervals estimated using a bootstrapping after 1000 replicates. Accessibility was computed using the Sfold (a) and the RNAfold (b) programs using SNPs from the African (AFR) population (see Additional file 1: Figure S12 for other populations)