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Fig. 4 | BMC Biology

Fig. 4

From: IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans

Fig. 4

Longevity of impt-1 knockdown models is additive to dietary and amino acid restriction. a Lifespan assays of eat-2(ad1116) worms treated with L4440 (control) or impt-1 RNAi from L1. b Lifespan assays of N2 and impt-1 +/– worms treated with L4440 or krs-1 RNAi from day 0 of adulthood. Values of median lifespan and statistics are reported in Additional file 10: Table S1. Survival curves were compared using the log-rank test. All experiments were repeated twice. Data demonstrate the composite of experiments VII–VIII (a) or IX–X (b)

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