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Fig. 7 | BMC Biology

Fig. 7

From: Geminin prevents DNA damage in vagal neural crest cells to ensure normal enteric neurogenesis

Fig. 7

Differential sensitivity  of pre-ENCCs and ENCCs to γ-irradiation. Cryosections at the level of the foregut of E10.0 Wnt1Cre|EYFP control embryos (ad), Wnt1Cre|EYFP embryos 2 hours (eh), or 5 hours (il) following exposure to IR, immunostained for GFP (green) and processed for TUNEL (red). Green and red arrows indicate the area of pre-ENCCs and ENCCs, respectively, magnified within a colour-matched frame. m, Quantification of GFP+ pre-ENCCs and ENCCs that are undergoing apoptosis (TUNEL+). Paired t-test between pre-ENCCs and ENCCs within each group, *P value < 0.05. One-way ANOVA followed by Fisher’s LSD multiple comparison test between the pre-ENCCs or the ENCCs of the three groups, ***P value < 0.001, ****P value < 0.0001. Scale bars: (ab, ef, ij) 100 μm, (cd, gh, kl) 25 μm

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