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Fig. 6 | BMC Biology

Fig. 6

From: Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development

Fig. 6

Tight regulation of both NIPI-3 and CEBP-1 is required in multiple tissues for proper organism development. ae Bright-field images and (f) the body length of worms expressing tissue-specific nipi-3(+) driven by the intestinal (mtl-2), epidermal (col-12) or pan-neuronal (rgef-1) promoters in a nipi-3(0) background. g The body length of worms expressing tissue-specific cebp-1(+) driven by the intestinal (ges-1), epidermal (col-154) or pan-neuronal (rgef-1) promoters in a nipi-3(0) cebp-1(0) background. f, g Each dot represents a single animal measured as shown; each red line represents the mean value; some data are replicated from Figs. 1 and 2 as shown with darker grey dots. **P < 0.01; ***P < 0.001; ns, not significant (one-way ANOVA with Tukey’s post hoc tests). h Working model for NIPI-3 function in C. elegans development. In wild type, presence of NIPI-3 keeps cebp-1 expression level optimal for coordinated tissue development. In nipi-3(0), however, cebp-1 and sek-1 are overexpressed and in turn PMK-1 is hyperactivated

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