Fig. 4.

Organizing mammalian transcriptional dynamics through modulating concentration, oligomerization, or epigenetic states. a Intranuclear concentration of p53 can exhibit either pulsatile (top) or sustained (bottom) changes when perturbed with different stimuli; cells with pulsatile response recover from DNA damage whereas those with sustained response enter senescence. b Regulating TF mobility and function through the dynamic interconversion among its monomeric, dimeric, and tetrameric forms. Depicted here is the case of STAT3, whose dimers must first translocate to the nucleus and bind DNA before forming tetramers, which could then amplify or repress STAT3 dimer-mediated transcription. c Immunofluorescence staining of four-cell mouse embryos reveals distinct differences in H3R26me2 levels (top); cells with a higher level (orange) exhibit a larger fraction of Sox2 engaged in long-lived DNA-binding than those with a lower level (blue) (bottom). Adapted from [118] (a), [124] (b), and [66] (c) with modifications