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Fig. 1 | BMC Biology

Fig. 1

From: Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway

Fig. 1

nipi-3(fr4) mutants have reduced resistance to ToxA, G418 and Pseudomonas aeruginosa. a Lifespans of wild type N2, nipi-3(fr4), and three independent lines of nipi-3(fr4) expressing wild type nipi-3p::nipi-3 fed E. coli expressing ToxA starting at the L4 stage. P < 0.0001 comparing nipi-3(fr4) and wild type (log-rank test). b Fraction of synchronized L1 worms that grew to at least young adult stage after 3 days at 20 °C on plates containing the indicated G418 concentration. Results shown are an average of four biological replicates. Error bars represent SD. *P < 0.05 compared to wild type animals at the given concentration (Student’s unpaired t-test). c Lifespans of wild type N2, nipi-3(fr4), and nipi-3(fr4) expressing wild type nipi-3p::nipi-3 fed on P. aeruginosa PA14. nipi-3(fr4);agEx120(-) indicates non-transgenic offspring of nipi-3p::nipi-3 transgenic worms. P < 0.001 comparing nipi-3(fr4) and wild type (log-rank test). Number of animals scored for each condition was ≥ 80 (547 total; a) and > 85 (487 total; c). These are representative experiments of two independent experiments. Primary data for panel b are provided in Additional file 15

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