Fig. 8
From: Search strategy is regulated by somatostatin signaling and deep brain photoreceptors in zebrafish
Model for induction of light search behavior by retinal and deep brain photosensory systems. a Loss of light detected via the retina drives an initial strong local search (red). Simultaneous stimulation of opn4a and sst1.1 signaling drives outward locomotor patterns for remote light sources (blue). Local search activity initially masks extended search locomotor features. b In enucleated larvae, lack of retinal drive allows remote light-search patterns to emerge immediately after loss of illumination. c In the absence of opn4a and sst1.1 to promote outward search in otpa mutants, retinal signaling continues to drive local search patterns for a longer period of time, as outward search drive is absent