Table 3 Analysis of ActRIIB-ECD on GDF8 and GDF11 activity by luciferase reporter assay
From: Structural basis for potency differences between GDF8 and GDF11
Ligand | Receptor | IC50 (nM) | IC50 (nM) 95% CIa | Log[IC50(M)] ± SEMb | Hill slope | Hill slope 95% CI |
|---|---|---|---|---|---|---|
GDF8 | ActRIIB-ECDc | 12.4 | 12.24 to 13.66 | −7.9 ± 0.02 | −1.73 | −1.99 to −1.47 |
GDF11 | 13.0 | 12.61 to 15.46 | −7.9 ± 0.02 | −1.57 | −1.79 to −1.35 | |
GDF8 | Fc-ActRIIB-ECD | 3.0 | 2.60 to 3.38 | −8.5 ± 0.03 | −2.24 | −2.82 to −1.65 |
GDF11 | 10.3 | 9.40 to 11.125 | −8.0 ± 0.02 | −8.05 | −10.46 to −5.63 |