Fig. 3

MiR-29 antagonism partially recapitulates aging. a, b KEGG pathway overrepresentation analysis on DEGs (FDR ≤ 0.05). The red and black asterisks indicate categories of DEGs regulated with age in the brain (from [47]). Red colored asterisk indicates categories that exhibit the same direction of regulation in both aging and tg(kif5aa:eGFP-sponge-29). Black colored asterisk indicates those with opposite regulation. Gray plus and minus symbols represent categories that positively and negatively correlates with lifespan respectively (from [52]) c Venn diagram illustrating the intersection between up and downregulated DEGs in sponge-29 and genes positively and negatively correlated with lifespan, respectively (P = 0.0007 and P = 0.0049, Fisher exact test). d Venn diagram illustrating the intersection between DEGs during aging and DEGs in sponge-29. e Correlation analysis of fold-changes of genes in the intersection shown in (d). Pie chart represents the fraction of genes coherently or incoherently regulated by aging and sponge-29