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Fig. 2 | BMC Biology

Fig. 2

From: Heterosis as a consequence of regulatory incompatibility

Fig. 2

Perturbed glucose-dependent respiration repression in the hybrid. a Reduced glucose-repression through upregulation of respiration gene expression in the hybrid. Each point represents a gene from the indicated group. Fold expression changes were calculated between the hybrid and the mean expression of S. cerevisiae and S. paradoxus. See Additional file 5: Table S1 for gene names and expression values. Data from [18]. b The hybrid consumes oxygen in the presence of glucose, but not its diploid parents. Shown are measurements of glucose and dissolved oxygen for cultures incubated into glucose-containing rich media (SD). Measurements were made during batch growth within a fermenter. c, d Hybrid mitochondria are larger and contain more cristae. c Representative electron microscopy (EM) images of mitochondria in the hybrid and its diploid parents grown in SD. d Quantification of mitochondria area and cristae of the hybrid and the diploid parents, from EM images. (N = ~20 mitochondria per strain). e Heterosis is lost when respiration is inhibited. Growth rates are shown for cells growing in SD in the presence or absence of the respiration inhibitor Antimycin A (N = 3)

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