Fig. 5

Gene sensitivity results indicate perturbation in several pathways. a The hybrid shows increased sensitivity to cell-cycle genes. Shown are z-scores of growth rates of strains hemizygote for genes coding for the G1/S transition that show reproducible effects in at least one condition. Missing values are shown in black. b The hybrid shows increased sensitivity to genes increasing cell size. Genes reported to increase cell size [50] are highly enriched within the set of genes showing hybrid-specific dosage sensitivity in at least one of the conditions (hypergeometric test). This increased sensitivity is independent of the functional association of these genes. c The hybrid shows high sensitivity to DNA damage genes, same as Fig. 5a for the indicated strains. d Hybrid hemizygote strains show high sensitivity to mitochondrial genes, same as Fig. 5a for the indicated genes, which code for proteins that localize to the mitochondria and are either nuclear or mitochondrial encoded