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Fig. 4 | BMC Biology

Fig. 4

From: The biological function of the cellular prion protein: an update

Fig. 4

Axonal PrPC promotes myelin maintenance in trans via Adgrg6 on Schwann cells. Mice devoid of PrPC develop a chronic demyelinating neuropathy, which suggested a pro-myelinating function of PrPC. In the peripheral nervous system, the N1 fragment of axonal PrPC interacts with Adgrg6 expressed on Schwann cells. This binding elicits activation of Adgrg6, which signals via adenylyl cyclase, thereby leading to increased cellular levels of cAMP. This triggers a well-defined downstream signaling cascade promoting myelin maintenance

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