Skip to main content

Table 1 Lines of PrPC-ablated mice covered in this review

From: The biological function of the cellular prion protein: an update

Name Year produced Reference Genetic background “Doppel artifact“
Zurich I (ZrchI, ZH1) 1992 [28] Mixed C57BL/6J x 129/Sv(ev) No
Edinburgh (Edbg) 1994 [29] 129/Ola No
Nagasaki (Ngsk) 1996 [31] Mixed C57BL/6J x 129/Sv(ev) Yes
Rcm0 1997 [33] Mixed C57BL/6J x 129/Sv(ev) Yes
Zurich II (ZrchII, ZH2) 2001 [34] Mixed C57BL/6J x 129/Sv(ev) Yes
NFH-Cre/tg37 (adult onset) 2002 [39] Mixed C57BL/6J x 129/Sv(ev) No
Zurich III (ZrchIII, ZH3) 2016 [42] C57BL/6J No
  1. Bold indicates mixed genetic background of at least two distinct mouse strains, possibly leading to the “flanking-gene problem”. Italic indicates mice maintained on single, pure genetic background
\