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Table 1 Lines of PrPC-ablated mice covered in this review

From: The biological function of the cellular prion protein: an update

Name

Year produced

Reference

Genetic background

“Doppel artifact“

Zurich I (ZrchI, ZH1)

1992

[28]

Mixed C57BL/6J x 129/Sv(ev)

No

Edinburgh (Edbg)

1994

[29]

129/Ola

No

Nagasaki (Ngsk)

1996

[31]

Mixed C57BL/6J x 129/Sv(ev)

Yes

Rcm0

1997

[33]

Mixed C57BL/6J x 129/Sv(ev)

Yes

Zurich II (ZrchII, ZH2)

2001

[34]

Mixed C57BL/6J x 129/Sv(ev)

Yes

NFH-Cre/tg37 (adult onset)

2002

[39]

Mixed C57BL/6J x 129/Sv(ev)

No

Zurich III (ZrchIII, ZH3)

2016

[42]

C57BL/6J

No

  1. Bold indicates mixed genetic background of at least two distinct mouse strains, possibly leading to the “flanking-gene problem”. Italic indicates mice maintained on single, pure genetic background