Fig. 6

Zymogen-locked endogenous matriptase supports intestinal barrier formation and epidermal regeneration. Histological appearance (a–e, h) and matriptase immunohistochemistry (e–h) of large (a, b, e, f) and small (c, d, g, h) intestine of 3-month-old St14 ^zym/zym mice (a, c, e, g) or wildtype littermates (b, d, f, h). Scale bar in (a) = 20 μm, representative for a–h. Scale bar in inset in (e) = 10 μm, representative for insets in e–h. i Concentration of FITC-labeled dextran in the blood of 4- to 8-week-old St14 ^zym/zym mice (n = 10), St14 ^zym/+ mice (n = 23), and St14 ^+/+ littermates (n = 14) 3 h after instillation of FITC-labeled dextran into the stomach by oral gavage. A small, but significant, increase in intestinal permeability was observed in St14 ^zym/zym mice as compared to littermate St14 ⁺ mice. One-way ANOVA, non-parametric, two tailed. j Rate of healing of 1.5-cm incisional skin wounds in St14 ⁺ (red, n = 10) mice and St14 ^zym/zym (blue, n = 8) littermates. Wound healing was not significantly delayed in St14 ^zym/zym mice relative to St14 ⁺ littermates. Additional file 1: Raw supporting data