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Fig. 10 | BMC Biology

Fig. 10

From: Non-model model organisms

Fig. 10

Cerebral organoids model the architecture of the developing human brain. Left: a section of an entire cerebral organoid stained for the forebrain marker Foxg1, the intermediate progenitor marker Tbr2, and DAPI, revealing the presence of lobules of cerebral cortex as well as other brain regions not positive for Foxg1. Right: a schematic of a lobule of cortex in an organoid showing the proper organization of progenitor zones: ventricular zone (VZ) where radial glial neural stem cells reside, subventricular zone (SVZ) where transit amplifying populations reside, and the intermediate zone (IZ) and cortical plate (CP) where neurons migrate to their final positions. Scattered pink puncta represent outer radial glia, a population abundant in human brain development but much less present in rodents, while elongated purple neurons represent tangentially migrating interneurons that originate outside the cortex. In the case of microcephaly (lower left) organoids overall are much smaller, as are progenitor zones [192], whereas organoids derived from autistic patients display increased numbers of interneurons [198]. Scale bar 100 μm

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