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Fig. 3. | BMC Biology

Fig. 3.

From: Tissue macrophages: heterogeneity and functions

Fig. 3.

Schematic illustration of F4/80 antigen expression by tissue-resident macrophages in the mouse. Monocytes and macrophages express F4/80 antigen after differentiation and proliferation of F4/80 negative precursors in the embryo (not shown) and bone marrow. Mature F4/80+ macrophages associate with endothelia and epithelia as they migrate through tissues. Monocytes (+/-) replenish F4/80+ tissue-resident macrophages, for example in gut, liver, skin and brain, and contribute to formation of F4/80-negative osteoclasts. Macrophages lining lung alveoli and in T-cell-rich lymphoid tissues express F4/80 weakly. See Gordon et al. [112] for further details

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