Skip to main content

Table 4 Leucines at the inner and outer leaflets of the membrane in TMHs

From: Charged residues next to transmembrane regions revisited: “Positive-inside rule” is complemented by the “negative inside depletion/outside enrichment rule”

Dataset Single-pass Multi-pass
Inside Outside Percentage H statistic P value Inside Outside Percentage H statistic P value
ExpAll 4020 3403 118.13 40.07 2.44E-10 27,986 27,008 103.62 14.13 1.70E-4
UniHuman 4982 3697 134.76 193.02 6.99E-44 25,199 22,365 112.67 195.24 2.29E-44
UniER 359 297 120.88 8.41 3.72E-3 1863 1764 105.61 3.98 4.61E-2
UniGolgi 604 513 117.74 10.74 1.05E-3 753 677 111.23 5.61 1.79E-2
UniPM 1485 1006 147.61 98.90 2.65E-23 6221 5577 111.55 35.21 3.00E-9
UniCress 1495 1005 148.76 102.05 5.41E-24 6491 6099 106.43 13.76 2.08E-4
UniFungi 1389 1308 106.19 3.41 6.48E-2 14,505 14,099 102.88 6.74 9.41E-3
UniBacilli 260 251 103.59 0.03 8.72E-1 1488 1335 111.46 7.59 5.89E-3
UniEcoli 130 100 130.00 2.78 9.53E-2 7251 6975 103.96 5.92 1.50E-2
UniArch 51 118 43.22 20.13 7.25E-6 636 612 103.92 0.24 6.25E-1
  1. The statistical results when comparing the number of leucine residues from the inner and outer leaflets in each protein in the dataset. The number of helices per dataset can be found in Table 1. The Kruskal-Wallis test scores (H statistics) were calculated for leucine residues by comparing the number of leucine residues that were in the inner half of the leaflet with those in the outer half of the leaflet of the database-defined TMH
\