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Table 4 Leucines at the inner and outer leaflets of the membrane in TMHs

From: Charged residues next to transmembrane regions revisited: “Positive-inside rule” is complemented by the “negative inside depletion/outside enrichment rule”

Dataset

Single-pass

Multi-pass

Inside

Outside

Percentage

H statistic

P value

Inside

Outside

Percentage

H statistic

P value

ExpAll

4020

3403

118.13

40.07

2.44E-10

27,986

27,008

103.62

14.13

1.70E-4

UniHuman

4982

3697

134.76

193.02

6.99E-44

25,199

22,365

112.67

195.24

2.29E-44

UniER

359

297

120.88

8.41

3.72E-3

1863

1764

105.61

3.98

4.61E-2

UniGolgi

604

513

117.74

10.74

1.05E-3

753

677

111.23

5.61

1.79E-2

UniPM

1485

1006

147.61

98.90

2.65E-23

6221

5577

111.55

35.21

3.00E-9

UniCress

1495

1005

148.76

102.05

5.41E-24

6491

6099

106.43

13.76

2.08E-4

UniFungi

1389

1308

106.19

3.41

6.48E-2

14,505

14,099

102.88

6.74

9.41E-3

UniBacilli

260

251

103.59

0.03

8.72E-1

1488

1335

111.46

7.59

5.89E-3

UniEcoli

130

100

130.00

2.78

9.53E-2

7251

6975

103.96

5.92

1.50E-2

UniArch

51

118

43.22

20.13

7.25E-6

636

612

103.92

0.24

6.25E-1

  1. The statistical results when comparing the number of leucine residues from the inner and outer leaflets in each protein in the dataset. The number of helices per dataset can be found in Table 1. The Kruskal-Wallis test scores (H statistics) were calculated for leucine residues by comparing the number of leucine residues that were in the inner half of the leaflet with those in the outer half of the leaflet of the database-defined TMH
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BMC Biology

ISSN: 1741-7007

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