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Table 5 Simple TMHs are less similar than complex TMHs to TMHs from multi-pass proteins in UniHuman

From: Charged residues next to transmembrane regions revisited: “Positive-inside rule” is complemented by the “negative inside depletion/outside enrichment rule”

Residues P values for χ2 Bahadur slopes for χ2
Simple-vs-complex Simple-vs-multi Complex-vs-multi Simple-vs-complex Simple-vs-multi Complex-vs-multi
 R 3.20E-06 7.38E-02 1.24E-01 6.61E-03 2.20E-03 1.27E-04
 K 2.23E-03 4.99E-02 2.14E-01 3.99E-03 3.70E-03 1.18E-04
 D 1.67E-09 3.06E-01 3.02E-01 3.34E-02 3.24E-03 1.20E-04
 E 3.80E-07 2.34E-01 2.31E-01 1.81E-02 3.05E-03 1.36E-04
 Y 3.86E-01 3.97E-01 2.11E-01 1.06E-03 1.47E-03 8.25E-05
 W 3.77E-03 2.97E-01 3.84E-01 8.52E-03 2.73E-03 1.13E-04
 L 3.59E-01 2.88E-01 3.21E-01 1.52E-04 3.92E-04 1.69E-05
 C 6.44E-01 3.97E-01 3.41E-01 4.29E-04 1.29E-03 8.57E-05
 R + K 2.19E-02 2.83E-01 2.52E-01 1.11E-03 6.33E-04 4.68E-05
 D + E 1.47E-03 2.86E-01 2.79E-01 4.59E-03 1.49E-03 6.15E-05
  P values for Kolmogorov-Smirnov Bahadur slopes for Kolmogorov-Smirnov
  Simple-vs-complex Simple-vs-multi Complex-vs-multi Simple-vs-complex Simple-vs-multi Complex-vs-multi
 R 2.31E-01 3.57E-04 1.08E-02 7.66E-04 6.71E-03 2.76E-04
 K 4.31E-02 2.18E-03 8.93E-01 2.06E-03 7.56E-03 8.68E-06
 D 1.39E-01 5.02E-06 1.08E-02 3.26E-03 3.34E-02 4.52E-04
 E 7.96E-02 1.58E-05 1.08E-02 3.10E-03 2.32E-02 4.20E-04
 Y 7.96E-02 2.22E-02 2.31E-01 2.81E-03 6.07E-03 7.78E-05
 W 2.31E-01 9.06E-04 4.31E-02 2.24E-03 1.58E-02 3.70E-04
 L 2.31E-01 2.31E-01 5.31E-01 2.17E-04 4.61E-04 9.42E-06
 C 1.39E-01 3.61E-01 3.61E-01 1.93E-03 1.42E-03 8.10E-05
 R + K 7.96E-02 1.33E-04 7.96E-02 7.35E-04 4.48E-03 8.60E-05
 D + E 4.31E-02 1.58E-05 4.98E-03 2.21E-03 1.31E-02 2.55E-04
  P values for Kruskal-Wallis Bahadur slopes for Kruskal-Wallis
  Simple-vs-complex Simple-vs-multi Complex-vs-multi Simple-vs-complex Simple-vs-multi Complex-vs-multi
 R 2.19E-01 5.06E-02 2.37E-01 7.92E-04 2.52E-03 8.79E-05
 K 2.90E-01 1.33E-01 7.00E-01 8.11E-04 2.49E-03 2.73E-05
 D 3.50E-01 1.81E-02 2.81E-01 1.74E-03 1.10E-02 1.27E-04
 E 2.59E-01 5.65E-02 1.78E-01 1.65E-03 6.04E-03 1.60E-04
 Y 6.03E-01 4.53E-01 4.41E-01 5.62E-04 1.26E-03 4.34E-05
 W 4.19E-01 1.84E-01 5.70E-01 1.33E-03 3.81E-03 6.62E-05
 L 6.37E-01 4.88E-01 9.77E-01 6.68E-05 2.25E-04 3.47E-07
 C 5.00E-01 2.22E-01 9.62E-01 6.76E-04 2.10E-03 3.11E-06
 R + K 1.87E-01 8.67E-02 4.08E-01 4.86E-04 1.23E-03 3.05E-05
 D + E 1.68E-01 4.52E-02 1.91E-01 1.25E-03 3.68E-03 7.97E-05
  1. The statistical results were gathered by comparing complex single-pass TMHs, simple TMHs from single-pass proteins and TMHs from multi-pass proteins in UniHuman. The abundance of different residues at each position when using the centrally aligned TMH approach was compared with several statistical tests (the Kolmogorov-Smirnov, Kruskal-Wallis and the χ2 statistical tests) and the Bahadur slope values of those results