Skip to main content

Table 5 Simple TMHs are less similar than complex TMHs to TMHs from multi-pass proteins in UniHuman

From: Charged residues next to transmembrane regions revisited: “Positive-inside rule” is complemented by the “negative inside depletion/outside enrichment rule”

Residues

P values for χ2

Bahadur slopes for χ2

Simple-vs-complex

Simple-vs-multi

Complex-vs-multi

Simple-vs-complex

Simple-vs-multi

Complex-vs-multi

 R

3.20E-06

7.38E-02

1.24E-01

6.61E-03

2.20E-03

1.27E-04

 K

2.23E-03

4.99E-02

2.14E-01

3.99E-03

3.70E-03

1.18E-04

 D

1.67E-09

3.06E-01

3.02E-01

3.34E-02

3.24E-03

1.20E-04

 E

3.80E-07

2.34E-01

2.31E-01

1.81E-02

3.05E-03

1.36E-04

 Y

3.86E-01

3.97E-01

2.11E-01

1.06E-03

1.47E-03

8.25E-05

 W

3.77E-03

2.97E-01

3.84E-01

8.52E-03

2.73E-03

1.13E-04

 L

3.59E-01

2.88E-01

3.21E-01

1.52E-04

3.92E-04

1.69E-05

 C

6.44E-01

3.97E-01

3.41E-01

4.29E-04

1.29E-03

8.57E-05

 R + K

2.19E-02

2.83E-01

2.52E-01

1.11E-03

6.33E-04

4.68E-05

 D + E

1.47E-03

2.86E-01

2.79E-01

4.59E-03

1.49E-03

6.15E-05

 

P values for Kolmogorov-Smirnov

Bahadur slopes for Kolmogorov-Smirnov

 

Simple-vs-complex

Simple-vs-multi

Complex-vs-multi

Simple-vs-complex

Simple-vs-multi

Complex-vs-multi

 R

2.31E-01

3.57E-04

1.08E-02

7.66E-04

6.71E-03

2.76E-04

 K

4.31E-02

2.18E-03

8.93E-01

2.06E-03

7.56E-03

8.68E-06

 D

1.39E-01

5.02E-06

1.08E-02

3.26E-03

3.34E-02

4.52E-04

 E

7.96E-02

1.58E-05

1.08E-02

3.10E-03

2.32E-02

4.20E-04

 Y

7.96E-02

2.22E-02

2.31E-01

2.81E-03

6.07E-03

7.78E-05

 W

2.31E-01

9.06E-04

4.31E-02

2.24E-03

1.58E-02

3.70E-04

 L

2.31E-01

2.31E-01

5.31E-01

2.17E-04

4.61E-04

9.42E-06

 C

1.39E-01

3.61E-01

3.61E-01

1.93E-03

1.42E-03

8.10E-05

 R + K

7.96E-02

1.33E-04

7.96E-02

7.35E-04

4.48E-03

8.60E-05

 D + E

4.31E-02

1.58E-05

4.98E-03

2.21E-03

1.31E-02

2.55E-04

 

P values for Kruskal-Wallis

Bahadur slopes for Kruskal-Wallis

 

Simple-vs-complex

Simple-vs-multi

Complex-vs-multi

Simple-vs-complex

Simple-vs-multi

Complex-vs-multi

 R

2.19E-01

5.06E-02

2.37E-01

7.92E-04

2.52E-03

8.79E-05

 K

2.90E-01

1.33E-01

7.00E-01

8.11E-04

2.49E-03

2.73E-05

 D

3.50E-01

1.81E-02

2.81E-01

1.74E-03

1.10E-02

1.27E-04

 E

2.59E-01

5.65E-02

1.78E-01

1.65E-03

6.04E-03

1.60E-04

 Y

6.03E-01

4.53E-01

4.41E-01

5.62E-04

1.26E-03

4.34E-05

 W

4.19E-01

1.84E-01

5.70E-01

1.33E-03

3.81E-03

6.62E-05

 L

6.37E-01

4.88E-01

9.77E-01

6.68E-05

2.25E-04

3.47E-07

 C

5.00E-01

2.22E-01

9.62E-01

6.76E-04

2.10E-03

3.11E-06

 R + K

1.87E-01

8.67E-02

4.08E-01

4.86E-04

1.23E-03

3.05E-05

 D + E

1.68E-01

4.52E-02

1.91E-01

1.25E-03

3.68E-03

7.97E-05

  1. The statistical results were gathered by comparing complex single-pass TMHs, simple TMHs from single-pass proteins and TMHs from multi-pass proteins in UniHuman. The abundance of different residues at each position when using the centrally aligned TMH approach was compared with several statistical tests (the Kolmogorov-Smirnov, Kruskal-Wallis and the χ2 statistical tests) and the Bahadur slope values of those results